In a new study released by the Indian Council of Medical Research (ICMR) stated that administering people a dose of Covishield, followed by Covaxin in the second dose is safe and improves immunity.
Covishield, developed by University of Oxford-AstraZeneca, is a viral vector vaccine that uses an adenovirus found in Chimpanzees, to deliver spike proteins and mount a tolerable immune response in response to a live virus, Covaxin, developed by the Hyderabad-based Bharat Biotech uses a similar inactive viral strain.
The regime for both the vaccines initially included a second homologous booster dose following a priming dose at an interval of 4 weeks.
“The findings suggest that immunisation with a combination of an adenovirus vector platform-based vaccine followed by an inactivated whole virus vaccine was not only safe but also elicited better immunogenicity,” revealed the study led by by Pune-based National Institute of Virology (NIV).
The study is not yet peer-reviewed and has been published pre-print on medRxiv.
During the national vaccination programme, 18 people from Audai Kalan village of Siddharthnagar district of eastern Uttar Pradesh, after receiving Covishield as the first dose, were inadvertently administered Covaxin in the second dose after an interval of six weeks.